lumefantrine will reduce the level or result of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.fedratinib will boost the amount or influence of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Change dose of medication which are CYP3A4 substrates as impor